ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 1426521-37-0
• Molecular Formula: C₁₆H₁₃FN₂O₂
• Molecular Weight: 284.29
• Mol file: 1426521-37-0.mol

Synonyms:ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property of ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate

There total 2 articles about ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 2-(pyridinyl-2)acetate (2739-98-2) + 4-fluorobenzonitrile (1194-02-1,143234-87-1) → ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate (1426521-37-0)

Guidance literature:

With copper diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; In dimethyl sulfoxide; at 60 - 65 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c5ob00018a

Reference yield:

4-fluoro-1-iodobenzene (352-34-1) + propynoic acid ethyl ester (623-47-2) → ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate (1426521-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 2.67 h / 20 - 55 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;

Reference yield: 69.0%

ethyl 2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate (1426521-37-0) + phenylboronic acid (98-80-6) → ethyl 2-([1,1'-biphenyl]-4-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:

With palladium diacetate; diisopropylamine; In water; at 100 ℃;

DOI:10.1039/c5ob00018a

upstream raw materials:

4-fluoro-1-iodobenzene

propynoic acid ethyl ester

ethyl 2-(pyridinyl-2)acetate

4-fluorobenzonitrile