(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

Base Information

Chemical Name:(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
CAS No.:143322-57-0
Molecular Formula:C14H17BrN2
Molecular Weight:293.206
Hs Code.:2933998350
European Community (EC) Number:422-390-5,690-723-3
UNII:XR1NS522CP
DSSTox Substance ID:DTXSID80458106
Wikidata:Q72447996
Mol file:143322-57-0.mol

Synonyms:143322-57-0;(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole;(R)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole;(R)-5-Bromo-3-(1-methyl-pyrrolidin-2-ylmethyl)-1H-indole;5-bromo-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole;Intermediate of Eletriptan;5-bromo-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-Indole;XR1NS522CP;(R)-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole;(R)-5-Bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-Indole;R-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole;5-Bromo-3-[1-methylpyrrolidin-2(R)-ylmethyl]-1H-indole;1H-Indole, 5-bromo-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-;EC 422-390-5;5-Bromo-3-(1-Methylpyrrolidin-2(R)-ylmethyl)-1H-Indole;(R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole;5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole;(R)-5-Bromo-3-[(1-methylpyrrolidin-2-yl)methyl]-1H-indole;MFCD00912970;1H-INDOLE, 5-BROMO-3-(((2R)-1-METHYL-2-PYRROLIDINYL)METHYL)-;UNII-XR1NS522CP;SCHEMBL697582;DTXSID80458106;BCP17560;CS-B0001;AKOS015834491;AKOS015895955;AM84391;CS-O-31541;CS-T-08577;DS-15028;V10027;EN300-1720827;J-502238;5-Bromo-3-(1-methypyrrolidin-2(R)-ylmethyl)-1H-indole;6-bromo-3-[(1-methylpyrrolidin-2-yl)methyl]-1H-indole;(r)-5-bromo-3-(1-methyl-2-pyrrolidinylmethyl)-1h-indole;(R)-5-Bromo-3-(N-methylpyrrolidin-2-yl-methyl)-1H-indole;(R)-5-bromo-3-(N-methylpyrrolidin-2ylmethyl)-1H-indole;3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-bromo-1H-indole;5-bromo-3-(N-methyl-2(R)-pyrrolidinylmethyl)-1H-indole;(R)-5-Bromo-3-[(N-methylpyrrolidin-2-yl)methyl] 1 H-indole;(R)-5-Bromo-3-[(N-methylpyrrolidin-2-yl)methyl]-1H-indole;5-Bromo-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole;5-Bromo-3-(1-Methyl pyrrolidin-2(R)-yl methyl)-1H-indole;5-Bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole, (R)-;(R)-5-Bromo-3-[(1-methylpyrrolidin-2-yl)methyl]-1H-indole 100 microg/mL in Acetonitrile

Suppliers and Price of (R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
5g
$ 725.00

TRC
(R)-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
500mg
$ 360.00

Labseeker
(R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole 98
10g
$ 308.00

Crysdot
(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole 95+%
5g
$ 223.00

Crysdot
(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole 95+%
10g
$ 371.00

Chemenu
(r)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1h-indole 95%
10g
$ 351.00

Chemenu
(r)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1h-indole 95%
5g
$ 211.00

Biosynth Carbosynth
R-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
10 mg
$ 199.90

Biosynth Carbosynth
R-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
5 mg
$ 109.90

Biosynth Carbosynth
R-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
25 mg
$ 363.50

Total 109 raw suppliers

Chemical Property of (R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

Chemical Property:

Vapor Pressure:5E-07mmHg at 25°C
Refractive Index:1.655
Boiling Point:412.9 °C at 760 mmHg
PKA:16.28±0.30(Predicted)
Flash Point:203.5 °C
PSA：19.03000
Density:1.418 g/cm³
LogP:3.50500
Storage Temp.:2-8°C
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:292.05751
Heavy Atom Count:17
Complexity:271

Purity/Quality:

98% ^*data from raw suppliers

(R)-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,N
Hazard Codes:T,N
Statements: 20/22-39-41-43-48/25-62-50/53
Safety Statements: 53-45-60-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCCC1CC2=CNC3=C2C=C(C=C3)Br
Isomeric SMILES:CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)Br
Uses 5-Bromo Eletriptan is an impurity of Eletriptan (E505000), which is A serotonin 5-HTIB/ID receptor agonist, used for the treatment of migraine headaches.

Technology Process of (R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

There total 10 articles about (R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 1196663-29-2
5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole ethanedioate

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: With sodium carbonate; In water; toluene; at 30 - 35 ℃; for 0.5h; pH=7.8;

Reference yield: 77.0%

: 143322-56-9,331842-86-5
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

: 143322-55-8
(R)-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole

: C₁₄H₁₇BrN₂O

: 180637-93-8
C₁₄H₁₅BrN₂O

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tert-butyl methyl ether; toluene; at 30 - 48 ℃; for 3.16667h;

With sodium hydroxide; water; In tert-butyl methyl ether; toluene; at 15 - 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 73.0%

: 143322-56-9,331842-86-5
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 30 - 50 ℃; for 1.66667 - 2h;

With sodium hydroxide; water; In tetrahydrofuran; toluene; at 5 - 25 ℃; Product distribution / selectivity;