1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione

Base Information

• Chemical Name: 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione
• CAS No.: 145846-66-8
• Molecular Formula: C₁₈H₂₄N₂O₃
• Molecular Weight: 316.4

Synonyms:1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione

Chemical Property of 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione

Chemical Property:

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Technology Process of 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione

There total 2 articles about 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

phenylglyoxylyl chloride (25726-04-9) + (S)-5-Isobutyl-2,2,3-trimethyl-imidazolidin-4-one (145846-65-7) → 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione (145846-66-8)

Guidance literature:

With triethylamine; In toluene; at 0 ℃; for 12h;

DOI:10.1139/cjc-76-2-234

Reference yield:

L-leucine-N-methylamide (64569-68-2) → 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione (145846-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / dimethylformamide / 24 h / Heating

2: 83 percent / Et₃N / toluene / 12 h / 0 °C

With triethylamine; In N,N-dimethyl-formamide; toluene;

DOI:10.1139/cjc-76-2-234

Reference yield: 95.0%

1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione (145846-66-8) → (S)-1-((R)-2-Hydroxy-2-phenyl-acetyl)-5-isobutyl-2,2,3-trimethyl-imidazolidin-4-one (145846-67-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 5h; under 760 Torr;

DOI:10.1007/BF00816850

upstream raw materials:

phenylglyoxylyl chloride

(S)-5-Isobutyl-2,2,3-trimethyl-imidazolidin-4-one

L-leucine-N-methylamide

Downstream raw materials:

(S)-1-((R)-2-Hydroxy-2-phenyl-acetyl)-5-isobutyl-2,2,3-trimethyl-imidazolidin-4-one

(S)-1-((S)-2-Hydroxy-2-phenyl-acetyl)-5-isobutyl-2,2,3-trimethyl-imidazolidin-4-one

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