64569-68-2

Upstream product

• 2743-60-4 L-Leucine ethyl ester 
• 74-89-5 methylamine 
• 61-90-5 L-leucine 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 2018-66-8 Z-Leu-OH 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 67308-27-4 N^α-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucinamide 
• 64569-67-1 (S)-benzyl 4-methyl-1-(methylamino)-1-oxopentan-2-ylcarbamate 

Downstream Products

• 95303-79-0 Z-Val-Leu-NHCH₃ 
• 32483-15-1 Ac-Leu-NHMe 
• 67120-01-8 (S)-4-Methyl-2-(3-phenyl-thioureido)-pentanoic acid methylamide 
• 5115-69-5 (S)-2-((S)-3-Methyl-1-methylcarbamoyl-butylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 145846-66-8 1-((S)-5-Isobutyl-2,2,3-trimethyl-4-oxo-imidazolidin-1-yl)-2-phenyl-ethane-1,2-dione 
• 145846-67-9 (S)-1-((R)-2-Hydroxy-2-phenyl-acetyl)-5-isobutyl-2,2,3-trimethyl-imidazolidin-4-one 
• 209161-46-6 (S)-1-((S)-2-Hydroxy-2-phenyl-acetyl)-5-isobutyl-2,2,3-trimethyl-imidazolidin-4-one 
• 129155-88-0 5-Isobutyl-2-(4-methoxy-phenyl)-3-methyl-1-oxy-2,3-dihydro-imidazol-4-one 
• 129155-80-2 (S)-1-Hydroxy-5-isobutyl-2-(4-methoxy-phenyl)-3-methyl-imidazolidin-4-one 
• 1000072-80-9 (2S)-N,4-dimethyl-2-((3-phenylaziridin-2-yl)methylamino)pentanamide 
• 517920-64-8 Boc-gSer(Bn)-CO-Leu-NHMe 

Relevant academic research and scientific papers

Asymmetric and Geometry-Selective α-Alkenylation of α-Amino Acids

Both E- and Z-N′-alkenyl urea derivatives of imidazolidinones may be formed selectively from enantiopure α-amino acids. Generation of their enolate derivatives in the presence of K+ and [18]crown-6 induces intramolecular migration of the alkeny

UNNATURAL AMINO ACIDS

The present invention relates to a process for the preparation compounds of Formula (I): Formula (I) wherein X, Z, Q, Ar, R1, R2, R3 and R4 are each as defined herein. The present invention also relates to processes for the preparation of the compounds of quaternary amino acids and hydantions, to compound of Formula(I), to intermediate compounds of Formula (II), to quaternary amino acid compounds of Formula (III) and to hydantoin compounds of Formula (IV).

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

SUBSTITUTED IMIDAZOHETEROCYCLES

The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

Squaric acid-based peptidic inhibitors of matrix metalloprotease-1

A series of squaric acid-peptide conjugates were synthesized and evaluated as inhibitors of MMP-1. The cyclobut-3-enedione core was substituted at the 3-position with several functional groups, such as -N(alkyl)OH, -NHOH, and -OH, that are designed to bind to the zinc atom in the active site of the metalloprotease. The 4-position of the cyclobut-3-enedione was derivatized with mono- or dipeptides that are designed to bind in the S1′ and S2′ subsites of the enzyme, and position the metal chelating group appropriately in the active site for binding to zinc. Positional scanning revealed that -N(Me)OH provided the highest level of inhibition among the chelating groups that were tested, and Leu-Tle-NHMe was the preferred amino acid sequence. A combination of these groups yielded an inhibitor with an IC50 value of 95 μM. For one inhibitor, conversion of one of the carbonyl groups on the cyclobut-3-enedione core to a thiocarbonyl group resulted in a 18-fold increase in potency, and yielded a compound with an IC50 value of 15 μM.

Conformational Investigation of α,β-Dehydropeptides. II. Synthesis of Model Dipeptides

Two series of models dipeptides: Ac-Pro-X-NHMe, where X = L-, D- and α,β-(Z)-Δ-Abu and L-, D- and α,β-(Z)-Δ-Leu, designed for conformational investigation of α,β-dehydroamino acid effect on peptide chain β-turn have been synthesized.

OXIDATIVE PREPARATION OF OPTICALLY ACTIVE N-HYDROXY-α-AMINO ACID AMIDES

Two routes are presented for the conversion of optically active α-amino acid amides into the title compounds.One route (route A) features the formation of the Schiff's base 6 which is subsequently oxidized to the corresponding oxaziridines 7.Route B is ch

PREPARATION, SPECTRAL AND PHYSICOCHEMICAL CHARACTERISTICS OF METHYLAMIDE Nα-PHENYLTHIOCARBAMOYL DERIVATIVES OF NATURALLY OCCURING AMINO ACIDS

The methylamide Nα-phenylthiocarbamoyl derivatives of encoded amino acids II were prepared either by the addition of phenylisothiocyanate to amino acid methylamides or by the treatment of amino acid phenylthiohydantoins (5-alkyl-3-phenyl-2-thioxo-4-imidazolinones) I with methylamine.The derivatives were prepared of 19 amino acids and their melting points, 1H NMR, 13C NMR, mass, ultraviolet and infrared spectra were measured.