2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one

Base Information

• Chemical Name: 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one
• CAS No.: 80517-10-8
• Molecular Formula: C₁₇H₁₂BrN₃OS₂
• Molecular Weight: 418.338
• Mol file: 80517-10-8.mol

Synonyms:2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one

Chemical Property of 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one

There total 3 articles about 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-amino-5-phenyl-1,3,4-thiadiazole (2002-03-1) + mercaptoacetic acid (68-11-1) + 4-bromo-benzaldehyde (1122-91-4) → 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one (80517-10-8)

Guidance literature:

With silica sulfuric acid; In ethanol; Reflux;

DOI:10.1080/00397911.2019.1643485

Reference yield: 75.0%

[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-(5-phenyl-[1,3,4]thiadiazol-2-yl)-amine (77420-74-7) + mercaptoacetic acid (68-11-1) → 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one (80517-10-8)

Guidance literature:

In ethanol; for 6h; Reflux;

Reference yield:

benzoic acid (65-85-0,8013-63-6) → 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one (80517-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / ethanol; water / 4 h / 80 - 90 °C

2: silica sulfuric acid / ethanol / Reflux

With sulfuric acid; In ethanol; water;

DOI:10.1080/00397911.2019.1643485

upstream raw materials:

[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-(5-phenyl-[1,3,4]thiadiazol-2-yl)-amine

mercaptoacetic acid

2-amino-5-phenyl-1,3,4-thiadiazole

4-bromo-benzaldehyde

Downstream raw materials:

C₂₄H₁₅Br₂N₃OS₂