methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

Base Information

• Chemical Name: methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate
• CAS No.: 1360918-07-5
• Molecular Formula: C₂₂H₂₁BrCl₂N₂O₄
• Molecular Weight: 528.23
• Mol file: 1360918-07-5.mol

Synonyms:methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

Chemical Property of methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

There total 4 articles about methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-5-(bromomethyl)-2,3-dichlorobenzene (960305-16-2) + methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride (1360911-54-1) → methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate (1360918-07-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 55 ℃; for 2h;

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) → methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate (1360918-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 55 °C

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester (169206-55-7) → methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate (1360918-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 55 °C

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

4-methoxycarbonylphenyl bromide

1-bromo-5-(bromomethyl)-2,3-dichlorobenzene

methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride

tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate