7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

Base Information

Chemical Name:7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol
CAS No.:1313438-39-9
Molecular Formula:C₂₆H₂₄N₄O
Molecular Weight:408.503
Hs Code.:

Synonyms:7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

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Chemical Property of 7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

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Technology Process of 7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

There total 6 articles about 7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1313439-95-0
tert-butyl (1-(4-(3-hydroxy-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

: 1313438-39-9
7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

Guidance literature:: With trifluoroacetic acid; for 0.00833333h;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1313438-39-9
7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 18 h / 80 °C / Inert atmosphere

2.1: acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

3.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere

3.2: 0.58 h / 20 °C / Inert atmosphere

3.3: 1.5 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

4.2: 20 °C

5.1: hydrazine hydrate / ethanol / 18 h / Inert atmosphere; Reflux

6.1: trifluoroacetic acid / 0.01 h

With potassium tert-butylate; hydrazine hydrate; acetic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 1313439-93-8
tert-butyl (1-(4-(6-(bis(methylthio)methylene)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinolin-2-yl)phenyl)cyclobutyl)carbamate

: 1313438-39-9
7-(4-(1-aminocyclobutyl)phenyl)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrazine hydrate / ethanol / 18 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / 0.01 h

With hydrazine hydrate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;