DIAZALD(R)-N-METHYL-D3

Base Information

• Chemical Name: DIAZALD(R)-N-METHYL-D3
• CAS No.: 42366-72-3
• Molecular Formula: C₈H₁₀N₂O₃S
• Molecular Weight: 217.221
• Mol file: 42366-72-3.mol

Synonyms:4-methylcyclohexyl p-toluenesulfonate;p-Toluolsulfonsaeure-;diazald-N-methyl-d3;4-methylcyclohexyl 4-methylbenzenesulfonate;cyclohexanol,4-methyl-,4-methylbenzenesulfonate;

Chemical Property of DIAZALD(R)-N-METHYL-D3

Chemical Property:

• Melting Point: 60-63oC
• PSA: 75.19000
• LogP: 2.37770
• Storage Temp.: 0-6°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-METHYL-D3-N-NITROSO-PARA-TOLUENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi,E
• Statements: 20/21/22-43-36/37/38-2
• Safety Statements: 26-36-36/37-35-15

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIAZALD(R)-N-METHYL-D3

There total 6 articles about DIAZALD(R)-N-METHYL-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-N-(methyl-d3)benzenesulfonamide (85894-45-7) → N-methyl-d3-N-nitroso-para-toluenesulfonamide (42366-72-3)

Guidance literature:

With sodium acetate; acetic acid; sodium chloride; sodium nitrite; In water; at 0 ℃;

DOI:10.1002/jlcr.3231

Reference yield:

toluene-4-sulfonamide (70-55-3) → N-methyl-d3-N-nitroso-para-toluenesulfonamide (42366-72-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; dmap / dichloromethane / 2.42 h / 23 °C

2: potassium carbonate / acetonitrile / 18 h / 80 °C

3: trifluoroacetic acid / neat (no solvent) / 1 h / 0 - 20 °C

4: sodium chloride; sodium acetate; sodium nitrite; acetic acid / water / 0 °C

With dmap; sodium acetate; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium chloride; sodium nitrite; In dichloromethane; water; acetonitrile;

DOI:10.1002/jlcr.3231

Reference yield:

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → N-methyl-d3-N-nitroso-para-toluenesulfonamide (42366-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 18 h / 80 °C

2: trifluoroacetic acid / neat (no solvent) / 1 h / 0 - 20 °C

3: sodium chloride; sodium acetate; sodium nitrite; acetic acid / water / 0 °C

With sodium acetate; potassium carbonate; acetic acid; trifluoroacetic acid; sodium chloride; sodium nitrite; In water; acetonitrile;

DOI:10.1002/jlcr.3231

upstream raw materials:

N-methyl-d₃ tert-butyl para-toluenesulfonylcarbamate

4-methyl-N-(methyl-d₃)benzenesulfonamide

p-toluenesulfonyl chloride

toluene-4-sulfonamide

Downstream raw materials:

diazomethane-d2

Refernces