C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

Base Information

Chemical Name:C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S
CAS No.:1380427-97-3
Molecular Formula:C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S
Molecular Weight:630.568
Hs Code.:

C<sub>2</sub>HF<sub>3</sub>O<sub>2</sub>*C<sub>25</sub>H<sub>23</sub>F<sub>3</sub>N<sub>4</sub>O<sub>3</sub>S

Synonyms:C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

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Chemical Property of C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

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Technology Process of C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

There total 6 articles about C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.8%

: 1380427-95-1
2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

: 76-05-1
trifluoroacetic acid

: 74-88-4
methyl iodide

: 1380427-97-3
C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

Guidance literature:: 2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one; methyl iodide; With N-ethyl-N,N-diisopropylamine; zinc dibromide; In chloroform; at 60 ℃; for 1h;

trifluoroacetic acid; In chloroform; water; acetonitrile;

Reference yield:

: 25016-11-9
1-methylpyrazole-4-carbaldehyde

: 1380427-97-3
C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine; pyridine / 4 h / 110 °C / Inert atmosphere

1.2: pH 1

2.1: methanol; sulfuric acid / 4 h / Reflux

3.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 - 40 °C

4.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

4.2: 50 °C

4.3: 1 h / pH 3 / Cooling with ice

5.1: thionyl chloride / chloroform / 2 h / 20 °C

5.2: 1 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine; zinc dibromide / chloroform / 1 h / 60 °C

With piperidine; pyridine; methanol; thionyl chloride; sulfuric acid; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;

Reference yield:

: 689251-97-6
(E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid

: 1380427-97-3
C₂HF₃O₂*C₂₅H₂₃F₃N₄O₃S

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; sulfuric acid / 4 h / Reflux

2.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 - 40 °C

3.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

3.2: 50 °C

3.3: 1 h / pH 3 / Cooling with ice

4.1: thionyl chloride / chloroform / 2 h / 20 °C

4.2: 1 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; zinc dibromide / chloroform / 1 h / 60 °C

With methanol; thionyl chloride; sulfuric acid; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;