33167-21-4

Basic information

• Product Name: 3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: ETHYL 3-(3-CHLOROPHENYL)-3-OXOPROPANOATE;ETHYL (3-CHLOROBENZOYL)ACETATE;3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;Ethyl 2-(3-chlorobenzoyl)acetate;3-Chloro--oxobenzenepropanoic acid ethyl ester;Ethyl (3-chlorobenzoyl)acetate >=97%;3-(3-chlorophenyl)-3-keto-propionic acid ethyl ester;3-(3-chlorophenyl)-3-oxopropanoic acid ethyl ester
• CAS NO: 33167-21-4
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• Product Categories: C10 to C11;Carbonyl Compounds;Esters;Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 33167-21-4.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 257-258 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.213 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000525mmHg at 25°C
• Refractive Index: n20/D 1.5460(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.91±0.46(Predicted)
• CAS DataBase Reference: 3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(33167-21-4)
• EPA Substance Registry System: 3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(33167-21-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 33167-21-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 33167-21-4 differently. You can refer to the following data:
1. Reagent / reactant involved in:? ;Oxidative cross-coupling via dioxygen activation with indoles1? ;Chlorination and hydrosilylation for synthesis of α-hydroxy β-amino acid derivatives2? ;Precursor for substrates for chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water3? ;Intramolecular cyclization for synthesis of dihydrofurans4? ;Rate acceleration of Michael reactions5? ;Cerium ammonium nitrate-mediated oxidative coupling6
2. Reagent / reactant involved in:Oxidative cross-coupling via dioxygen activation with indolesChlorination and hydrosilylation for synthesis of α-hydroxy β-amino acid derivativesPrecursor for substrates for chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and waterIntramolecular cyclization for synthesis of dihydrofuransRate acceleration of Michael reactionsCerium ammonium nitrate-mediated oxidative coupling

InChI:InChI=1/C11H11ClO3/c1-2-15-11(14)7-10(13)8-4-3-5-9(12)6-8/h3-6H,2,7H2,1H3

Upstream product

• 618-46-2 m-Chlorobenzoyl chloride 
• 105-36-2 ethyl bromoacetate 
• 99-02-5 3'-Chloroacetophenone 
• 105-58-8 Diethyl carbonate 
• 535-80-8 3-chlorobenzoate 
• 42428-03-5 (3-chlorophenyl)(1H-imidazol-1-yl)methanone 
• 6148-64-7 ethyl potassium malonate 
• 64-17-5 ethanol 
• 893643-63-5 2-(3-chloro-benzoyl)-3-oxo-butyric acid ethyl ester 

Downstream Products

• 36309-40-7 6-(3-chlorophenyl)-2-thiouracil 
• 76519-46-5 2-Amino-6-(3-chloro-phenyl)-3H-pyrimidin-4-one 
• 1026608-91-2 2-(3-Chloro-benzoyl)-pentanedioic acid diethyl ester 
• 194466-59-6 2-(3'-Chlorophenyl)-7-methyl-pyrido[1,2-a]pyrimidin-4-one 
• 805231-20-3 [2-(3-chlorophenyl)-[1,3]dioxolan-2-yl]acetic acid ethyl ester 
• 1088254-50-5 C₂₆H₂₈ClNO₃S 
• 1088254-35-6 C₂₁H₂₆ClNO₃S 
• 1088254-27-6 diethyl 2-methyl-4-ethyl-6-(3-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 1242162-71-5 ethyl 2-(3-chlorobenzoyl)pent-4-ynoate 
• 883989-27-3 (±)-4-(3-chlorophenyl)-2-(4-nitrophenoxy)-1,3,2-dioxaphosphinane-2-oxide 

Relevant articles and documents

Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines

A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C?C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.

Phosphoryl N - fatty acyl nucleoside analogues for treatment of viral hepatitis and liver cancer

The invention discloses a phosphoryl N-fatty acyl nucleoside analogue for treating viral hepatitis and liver cancer. The phosphoryl N-fatty acyl nucleoside analogue is characterized in that a nucleoside analogue is modified by a cyclophosphoryl group and

Radical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysis

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive molecules. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermolecular cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity.