N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

Base Information

Chemical Name:N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide
CAS No.:1335136-62-3
Molecular Formula:C₂₀H₂₃ClN₂O₃
Molecular Weight:374.867
Hs Code.:

Synonyms:N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

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Chemical Property of N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

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Technology Process of N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

There total 4 articles about N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.7%

: 617-88-9
2-Chloromethylfuran

: 8-azabicyclo[3.2.1]oct-3α-yl-5-chloro-2-methoxybenzamide hydrochloride

: 1335136-62-3
N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

Guidance literature:: 8-azabicyclo[3.2.1]oct-3α-yl-5-chloro-2-methoxybenzamide hydrochloride; With potassium carbonate; In acetone; for 0.0833333h;

2-Chloromethylfuran; In acetone; for 4h; Reflux;
DOI:10.1016/j.ejmech.2011.07.022

Reference yield:

: 130669-68-0
8-methyl-8-azabicyclo[3.2.1]oct-3α-yl-5-chloro-2-methoxybenzamide

: 1335136-62-3
N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-Chloroethyl chloroformate / 1,2-dichloro-ethane / 2 h / 20 °C

1.2: 1.5 h / Reflux

2.1: potassium carbonate / acetone / 0.08 h

2.2: 4 h / Reflux

With potassium carbonate; 2-Chloroethyl chloroformate; In 1,2-dichloro-ethane; acetone;
DOI:10.1016/j.ejmech.2011.07.022

Reference yield:

: 87571-88-8
3-endo-tropanamine

: 1335136-62-3
N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3α-yl)-5-chloro-2 methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / benzene / 3 h / Reflux

1.2: 24 h / 20 °C

2.1: 2-Chloroethyl chloroformate / 1,2-dichloro-ethane / 2 h / 20 °C

2.2: 1.5 h / Reflux

3.1: potassium carbonate / acetone / 0.08 h

3.2: 4 h / Reflux

With thionyl chloride; potassium carbonate; 2-Chloroethyl chloroformate; In 1,2-dichloro-ethane; acetone; benzene;
DOI:10.1016/j.ejmech.2011.07.022