(2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

Base Information

Chemical Name:(2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester
CAS No.:415975-56-3
Molecular Formula:C₂₂H₂₂Cl₂O₃
Molecular Weight:405.321
Hs Code.:

Synonyms:(2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

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Chemical Property of (2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

Chemical Property:

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Technology Process of (2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

There total 5 articles about (2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25501-32-0
(S)-indanol

: (S)-(3,4-Dichloro-phenyl)-(R)-tetrahydro-pyran-2-yl-acetyl chloride

: 415975-55-2
(2S,2R')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

: 415975-56-3
(2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/jm0205292

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 415975-56-3
(2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / HCl gas / diethyl ether / 2 h

2.1: LDA / hexane; tetrahydrofuran / 2 h / 0 °C

2.2: 1.6 g / hexane; tetrahydrofuran / 22 °C

3.1: 36 percent / trimethylsilyl iodide / CHCl₃ / 80 °C

4.1: DMF; (COCl)2 / CH₂Cl₂ / 2.5 h

5.1: 0.5 g / pyridine / tetrahydrofuran / 2 h / 0 °C

With pyridine; hydrogenchloride; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform;
DOI:10.1021/jm0205292

Reference yield:

: 3136-02-5
2-chlorotetrahydro-2H-pyran

: 415975-56-3
(2R,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid indanyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / hexane; tetrahydrofuran / 2 h / 0 °C

1.2: 1.6 g / hexane; tetrahydrofuran / 22 °C

2.1: 36 percent / trimethylsilyl iodide / CHCl₃ / 80 °C

3.1: DMF; (COCl)2 / CH₂Cl₂ / 2.5 h

4.1: 0.5 g / pyridine / tetrahydrofuran / 2 h / 0 °C

With pyridine; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1021/jm0205292