2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Name:2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1616474-11-3
Molecular Formula:C₂₅H₁₉ClN₄O₃S
Molecular Weight:490.97
Hs Code.:

Synonyms:2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

There total 6 articles about 2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 934524-10-4
2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine

: 1595291-53-4
3-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)pyridine

: 1616474-11-3
2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

: 1616474-12-4
C₁₈H₁₃ClN₄O

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2014.05.033

Reference yield:

: 6959-48-4
3-chloromethylpyridinium chloride

: 1616474-11-3
2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 - 80 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 1 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; caesium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: |Miyaura Borylation Reaction / 3: |Suzuki Coupling;
DOI:10.1016/j.tet.2014.05.033

Reference yield:

: 39929-79-8
7-deazaxanthine

: 1616474-11-3
2-chloro-4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 18 h / 75 - 105 °C

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 1 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 3: |Suzuki Coupling;
DOI:10.1016/j.tet.2014.05.033