(S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate

Base Information

• Chemical Name: (S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate
• CAS No.: 941293-48-7
• Molecular Formula: C₂₄H₃₅O₈PS
• Molecular Weight: 514.577
• Mol file: 941293-48-7.mol

Synonyms:(S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate

Chemical Property of (S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate

There total 1 articles about (S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate (941293-70-5) + p-toluenesulfonyl chloride (98-59-9) → (S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate (941293-48-7)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 25h;

Reference yield: 86.0%

(S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate (941293-48-7) → (S)-1-O-benzyl-2-O-<(diisopropylphosphono)methyl>-3-fluoro-1,2-propanediol (151223-08-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; at 100 - 110 ℃; for 6.5h;

DOI:10.1016/j.tet.2019.130529

Reference yield: 81.0%

(S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate (941293-48-7) → (2S)-2-[(diisopropylphosphoryl)methoxy]-3-hydroxypropyl p-tolylsulfonate (941293-49-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 24h; under 760.051 Torr;

upstream raw materials:

diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

p-toluenesulfonyl chloride

Downstream raw materials:

(2S)-2-[(diisopropylphosphoryl)methoxy]-3-hydroxypropyl p-tolylsulfonate

(S)-1-O-benzyl-2-O-<(diisopropylphosphono)methyl>-3-fluoro-1,2-propanediol