(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

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Chemical Name:(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid
CAS No.:1055041-46-7
Molecular Formula:C₃₄H₅₂N₄O₉
Molecular Weight:660.808
Hs Code.:

(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Synonyms:(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

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Chemical Property of (2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

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Technology Process of (2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

There total 8 articles about (2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6338-55-2
2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

: 1055041-46-7
(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

3: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

5: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

6: ethanol / 24 h / 80 °C

7: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm950641i

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 1055041-46-7
(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

3: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

5: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

6: ethanol / 24 h / 80 °C

7: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm950641i

Reference yield:

: ((S)-1-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethylcarbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester

: 1055041-46-7
(2R,3R,4S)-2-[3-(2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-ethoxy)-benzylamino]-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

2: K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

3: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

4: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

5: ethanol / 24 h / 80 °C

6: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm950641i