N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide
CAS No.:1431291-15-4
Molecular Formula:C₅₈H₆₉FN₂O₈Si
Molecular Weight:969.278
Hs Code.:

N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Synonyms:N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

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Chemical Property of N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

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Technology Process of N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

There total 15 articles about N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1431291-14-3
2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

: 1431291-15-4
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-12-1
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

: 1431291-15-4
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium hydroxide, 20 wt% on carbon / ethyl acetate / 8 h / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 6 h / 20 °C / Inert atmosphere

4: camphor-10-sulfonic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; palladium hydroxide, 20 wt% on carbon; camphor-10-sulfonic acid; hydrogen; Dess-Martin periodane; In dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-13-2
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

: 1431291-15-4
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 6 h / 20 °C / Inert atmosphere

3: camphor-10-sulfonic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; camphor-10-sulfonic acid; Dess-Martin periodane; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/ejoc.201201154