N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide
CAS No.:1431291-13-2
Molecular Formula:C₆₁H₇₇FN₂O₈Si
Molecular Weight:1013.37
Hs Code.:

N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Synonyms:N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

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Chemical Property of N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

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Technology Process of N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

There total 13 articles about N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1431291-12-1
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

: 1431291-13-2
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Guidance literature:: With palladium hydroxide, 20 wt% on carbon; hydrogen; In ethyl acetate; for 8h; Inert atmosphere;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-08-5
4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)aniline

: 1431291-13-2
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium hydroxide, 20 wt% on carbon / ethyl acetate / 8 h / Inert atmosphere

With palladium hydroxide, 20 wt% on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; ethyl acetate;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-04-1
C₂₅H₃₆O₄Si

: 1431291-13-2
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 5 h / 20 - 70 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogen; palladium hydroxide, 20 wt% on carbon / ethyl acetate / 8 h / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium hydroxide, 20 wt% on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; ethyl acetate; toluene;
DOI:10.1002/ejoc.201201154