2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

Base Information

Chemical Name:2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid
CAS No.:1431291-14-3
Molecular Formula:C₆₁H₇₅FN₂O₉Si
Molecular Weight:1027.36
Hs Code.:

2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

Synonyms:2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

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Chemical Property of 2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

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Technology Process of 2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

There total 14 articles about 2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₁H₇₅FN₂O₈Si

: 1431291-14-3
2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-13-2
N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

: 1431291-14-3
2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 6 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; Dess-Martin periodane; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-08-5
4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)aniline

: 1431291-14-3
2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium hydroxide, 20 wt% on carbon / ethyl acetate / 8 h / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 6 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; palladium hydroxide, 20 wt% on carbon; hydrogen; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1002/ejoc.201201154