1-N-Cbz-2-Methylpiperazine

Base Information

• Chemical Name: 1-N-Cbz-2-Methylpiperazine
• CAS No.: 444666-46-0
• Molecular Formula: C13H18N2O2
• Molecular Weight: 234.298
• Hs Code.: 2933599090
• Mol file: 444666-46-0.mol

Synonyms:Benzyl2-methylpiperazine-1-carboxylate;

Chemical Property of 1-N-Cbz-2-Methylpiperazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 358.024 °C at 760 mmHg
• PKA: 8.48±0.40(Predicted)
• Flash Point: 170.327 °C
• PSA: 41.57000
• Density: 1.105g/cm³
• LogP: 1.88360
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

Benzyl2-Methylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-N-Cbz-2-Methylpiperazine

There total 2 articles about 1-N-Cbz-2-Methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.4%

(RS)-2-methylpiperazine (109-07-9) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-methylpiperazine-1-carboxylate (444666-46-0,923565-98-4)

Guidance literature:

With sodium hydroxide; In water; butan-1-ol; at 23 - 26 ℃; for 2h; pH=7.5 - 8.5; Product distribution / selectivity;

Reference yield:

(RS)-2-methylpiperazine (109-07-9) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-methylpiperazine-1-carboxylate (444666-46-0,923565-98-4) + benzyl 3-methylpiperazine-1-carboxylate (84477-85-0)

Guidance literature:

With hydrogenchloride; In water; for 48h; pH=2 - 3;

DOI:10.1007/s11030-020-10158-3

Reference yield: 80.0%

benzyl 2-methylpiperazine-1-carboxylate (444666-46-0,923565-98-4) + p-benzyloxyphenylbromide (6793-92-6) → benzyl 4-(4-(benzyloxy)phenyl)-2-methylpiperazine-1-carboxylate

Guidance literature:

benzyl 2-methylpiperazine-1-carboxylate; p-benzyloxyphenylbromide; With caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; for 0.166667h; Inert atmosphere;

With palladium diacetate; In toluene; at 100 ℃; Sealed tube; Inert atmosphere;

upstream raw materials:

(RS)-2-methylpiperazine

benzyl chloroformate

Downstream raw materials:

benzyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]methyl}-2-methylpiperazine-1-carboxylate

benzyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]sulfonyl}-2-methylpiperazine-1-carboxylate

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