84477-85-0

Usage

Uses

Used in Pharmaceutical Industry:
1-N-CBZ-3-METHYL PIPERAZINE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its role in the development of new drugs is crucial, as it can be incorporated into the molecular structures of medications to enhance their therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-N-CBZ-3-METHYL PIPERAZINE is utilized as an intermediate in the production of agrochemicals. It contributes to the formulation of pesticides and other agricultural chemicals that are designed to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
1-N-CBZ-3-METHYL PIPERAZINE is used as a chemical building block in organic synthesis. It is a key component in the creation of complex organic molecules, which can be used in a wide range of applications, from pharmaceuticals to specialty chemicals.
Used in Chemical Production:
As a reagent, 1-N-CBZ-3-METHYL PIPERAZINE is employed in the production of various chemical products. Its versatility in chemical reactions makes it a valuable asset in the synthesis of a broad spectrum of compounds for different industries.

Upstream product

• 109-07-9 (RS)-2-methylpiperazine 
• 501-53-1 benzyl chloroformate 
• 74879-18-8 (S)-2-methylpiperazine 
• 300561-17-5 N-benzyloxycarbonyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamide 
• 215657-34-4 N-benzyloxycarbonyl-N-(2-fluorophenyl)methanesulfonamide 

Downstream Products

• 84477-87-2 H-7 
• 84477-86-1 1-benzyloxycarbonyl-4-(5-isoquinolinesulfonyl)-3-methylpiperazine 

Relevant academic research and scientific papers

Design, synthesis and SAR of antitubercular benzylpiperazine ureas

Abstract: N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to molecule (I) with an MIC of 1?μM against Mtb H37Rv, low cellular toxicity (HepG2 IC50 ~ 80?μM), good DMPK properties and specificity for Mtb. With the aim of delineating the SAR associated with (I), fifty-five analogs were synthesized and screened against Mtb. The SAR suggests that the piperazine ring, benzyl urea and piperonyl moieties are essential signatures of this series. Active compounds in this series are metabolically stable, have low cellular toxicity and are valuable leads for optimization. Molecular docking suggests these molecules occupy the Q0 site of QcrB like Q203. Graphic Abstract: Bioisosteric replacement of N-furfuryl piperazine-1-carboxamides yielded molecule (I) a novel lead with satisfactory PD, metabolism, and toxicity profiles.[Figure not available: see fulltext.]

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Microwave-assisted carbamoylation of amines

The influence of microwave irradiation on the reaction of various amines with benzyl chloroformate and di-tert-butyl dicarbonate was investigated. Microwave irradiation was successfully applied to the carbamoylation of several nonfunctionalized and functionalized amines, including amino acids and nucleobases, leading to satisfactory to high product conversion within very short reaction times. Copyright Taylor & Francis Group, LLC.

PROCESS FOR PRODUCING OXYCARBONYL-SUBSTITUTED PIPERAZINE DERIVATIVE

If an organic solvent with a water content of 15% or less is used when an oxycarbonyl-substituted piperazine derivative is produced from a piperazine derivative, the piperazine derivative can be oxycarbonylated.

Cyanophenyl derivative

This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.

CYANOPHENYL DERIVATIVES

This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.

Studies on development of sufficiently chemoselective N-acylation reagents: N-Acyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides

A variety of storable N-acyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides (4a-e) prepared from N-2,3,4,5,6-pentafluorophenylmethanesulfonamide (3), have been developed after systematic research on the structure-reactivity relationship and were found to serve as N-acylation reagents exhibiting sufficiently good chemoselectivity. (C) 2000 Elsevier Science Ltd.

A versatile synthon for chemoselective N-acylation reagents, 2-fluoro-N-mesylaniline

2-Fluoro-N-mesylaniline 3b undergoes various N-acylalions easily to give 2-fluoro-N-acyl-N-mesylanilines 4b-8b, which function as good chemoselective N-acylation reagents, especially for benzyloxycarbonylation.

5-Isoquinolinesulfonamide derivatives. III. Synthesis and vasodilatory activity of 1-(5-isoquinolinesulfonyl)piperazine derivatives

On the basis of a hypothesis that cyclization and alkylation of the diamine part in formula 1 may give highly active compounds, a new series of 5-isoquinolinesulfonamide derivatives, shown as formula 2, were prepared from cyclic diamines. Their vasodilatory effects were subsequently evaluated in vivo according to the increase in arterial blood flow after the formulas were injected locally to the femoral and/or vertebral arteries of dogs. Cyclization of the diamine structure in formula 1 gave very potent vasodilators: 6 and 14. Acylation and sulfonylation of terminal amino nitrogen afforded much less potent compounds. In contrast to the hypothesis, alkylation on the ring carbon and the terminal nitrogen of the cyclic amine afforded less active compounds except for compound 11. The most active compounds, 6, 11 and 14, showed more potent vasodilatory effects and more selective activity to the vertebral artery than either trapidil or diltiazem.