{5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester

Base Information

• Chemical Name: {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester
• CAS No.: 1301167-76-9
• Molecular Formula: C₂₅H₂₄N₄O₃
• Molecular Weight: 428.491
• Mol file: 1301167-76-9.mol

Synonyms:{5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester

Chemical Property of {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester

There total 8 articles about {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethyl-2-[4-(4-(pyridin-4-yl)-2H-pyrazol-3-yl)phenoxymethyl]pyridine (1320293-08-0) + bromoacetic acid methyl ester (96-32-2) → {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester (1301167-76-9) + C25H24N4O3 (1301167-75-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jm200536d

Reference yield:

C15H15NO3 → {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester (1301167-76-9) + C25H24N4O3 (1301167-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / -78 °C

4.1: 1 h / Reflux

4.2: 1 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With thionyl chloride; caesium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm200536d

Reference yield:

1-[4-(3,5-dimethylpyridin-2-yl)methoxyphenyl]-2-pyridin-4-ylethanone (1320293-07-9) → {5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester (1301167-76-9) + C25H24N4O3 (1301167-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1 h / Reflux

1.2: 1 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm200536d

upstream raw materials:

4-(3,5-dimethylpyridin-2-ylmethoxy)benzoic acid methyl ester

4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide

1-[4-(3,5-dimethylpyridin-2-yl)methoxyphenyl]-2-pyridin-4-ylethanone

3,5-dimethyl-2-[4-(4-(pyridin-4-yl)-2H-pyrazol-3-yl)phenoxymethyl]pyridine

Downstream raw materials:

2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol