4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide

Base Information

• Chemical Name: 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide
• CAS No.: 1320293-04-6
• Molecular Formula: C₁₇H₂₀N₂O₃
• Molecular Weight: 300.357
• Mol file: 1320293-04-6.mol

Synonyms:4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide

Chemical Property of 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide

There total 5 articles about 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H14ClNO2 + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide (1320293-04-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm200536d

Reference yield:

C15H15NO3 → 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide (1320293-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm200536d

Reference yield:

4-(3,5-dimethylpyridin-2-ylmethoxy)benzoic acid methyl ester (1320293-01-3) → 4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide (1320293-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C

1.2: pH 6 - 7

2.1: thionyl chloride / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1021/jm200536d

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

4-(3,5-dimethylpyridin-2-ylmethoxy)benzoic acid methyl ester

2-hydroxymethyl-3,5-dimethylpyridine

methyl 4-hydroxylbenzoate

Downstream raw materials:

1-[4-(3,5-dimethylpyridin-2-yl)methoxyphenyl]-2-pyridin-4-ylethanone

{5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester

C₂₅H₂₄N₄O₃

3,5-dimethyl-2-[4-(4-(pyridin-4-yl)-2H-pyrazol-3-yl)phenoxymethyl]pyridine