2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol

Base Information

• Chemical Name: 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol
• CAS No.: 1301167-77-0
• Molecular Formula: C₂₄H₂₄N₄O₂
• Molecular Weight: 400.48
• Mol file: 1301167-77-0.mol

Synonyms:2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol

Chemical Property of 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol

There total 9 articles about 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

{5-[4-(3,5-dimethylpyridin-2-ylmethoxy)-phenyl]-4-pyridin-4-yl-pyrazol-1-yl}-acetic acid methyl ester (1301167-76-9) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol (1301167-77-0)

Guidance literature:

With sodium borohydrid; In methanol;

Reference yield:

3,5-dimethyl-2-[4-(4-(pyridin-4-yl)-2H-pyrazol-3-yl)phenoxymethyl]pyridine (1320293-08-0) + bromoacetic acid methyl ester (96-32-2) → 2-[5-[4-(3,5-dimethyl-pyridin-2-ylmethoxy)phenyl]-4-pyridin-4-ylpyrazol-1-yl]ethanol (1320293-30-8) + 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol (1301167-77-0)

Guidance literature:

3,5-dimethyl-2-[4-(4-(pyridin-4-yl)-2H-pyrazol-3-yl)phenoxymethyl]pyridine; bromoacetic acid methyl ester; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm200536d

Reference yield:

4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide (1320293-04-6) → 2-[5-[4-(3,5-dimethyl-pyridin-2-ylmethoxy)phenyl]-4-pyridin-4-ylpyrazol-1-yl]ethanol (1320293-30-8) + 2-[3-[4-(3,5-dimethylpyridin-2-yl)methoxy]phenyl-4-pyridin-4-ylpyrazol-1-yl]ethanol (1301167-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0.5 h / -78 °C

2.1: 1 h / Reflux

2.2: 1 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 1 h / 20 °C

With caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm200536d

upstream raw materials:

4-(3,5-dimethylpyridin-2-ylmethoxy)benzoic acid methyl ester

4-(3,5-dimethylpyridin-2-ylmethoxy)-N-methoxy-N-methylbenzamide

1-[4-(3,5-dimethylpyridin-2-yl)methoxyphenyl]-2-pyridin-4-ylethanone

3,5-dimethyl-2-[4-(4-(pyridin-4-yl)-2H-pyrazol-3-yl)phenoxymethyl]pyridine

Downstream raw materials:

2-[4-[1-(2-⁽¹⁸⁾F-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine