3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

Base Information

Chemical Name:3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid
CAS No.:1202575-37-8
Molecular Formula:C₁₉H₁₈ClF₃O₄
Molecular Weight:402.798
Hs Code.:

Synonyms:3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

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Chemical Property of 3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

Chemical Property:

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Technology Process of 3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

There total 5 articles about 3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1202576-98-4
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

: 1202575-37-8
3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

Guidance literature:: Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

With hydrogenchloride; In water;

Reference yield:

: 1202576-95-1
1-(4-chlorophenyl)-2,2,2-trifluoroethyl trifluoromethanesulfonate

: 1202575-37-8
3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: silver(l) oxide / toluene / 20 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 20 °C

With water; caesium carbonate; sodium hydroxide; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 72487-06-0,80418-11-7,446-66-2
1-(4-chlorophenyl)-2,2,2-trifluoroethanol

: 1202575-37-8
3-{4-[1-(4-Chlorophenyl)-2,2,2-trifluoro ethoxy]phenyl}-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / diethyl ether / 0 °C

1.2: 2 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

4.1: silver(l) oxide / toluene / 20 °C

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 20 °C

With water; sodium hydride; caesium carbonate; sodium hydroxide; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene;