Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

Base Information

Chemical Name:Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate
CAS No.:1202576-97-3
Molecular Formula:C₁₉H₁₈ClF₃O₄
Molecular Weight:402.798
Hs Code.:

Synonyms:Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

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Chemical Property of Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

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Technology Process of Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

There total 3 articles about Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1202576-96-2
4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]benzaldehyde

: 141-78-6
ethyl acetate

: 1202576-97-3
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

Guidance literature:: ethyl acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Reference yield:

: 1202576-95-1
1-(4-chlorophenyl)-2,2,2-trifluoroethyl trifluoromethanesulfonate

: 1202576-97-3
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

With caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 72487-06-0,80418-11-7,446-66-2
1-(4-chlorophenyl)-2,2,2-trifluoroethanol

: 1202576-97-3
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / diethyl ether / 0 °C

1.2: 2 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

With sodium hydride; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;