Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

Base Information

Chemical Name:Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate
CAS No.:1202576-98-4
Molecular Formula:C₂₁H₂₂ClF₃O₄
Molecular Weight:430.851
Hs Code.:

Synonyms:Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

Chemical Property:

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Technology Process of Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

There total 4 articles about Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1202576-97-3
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-hydroxypropionate

: 75-03-6
ethyl iodide

: 1202576-98-4
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

Guidance literature:: With silver(l) oxide; In toluene; at 20 ℃;

Reference yield:

: 1202576-95-1
1-(4-chlorophenyl)-2,2,2-trifluoroethyl trifluoromethanesulfonate

: 1202576-98-4
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: silver(l) oxide / toluene / 20 °C

With caesium carbonate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 72487-06-0,80418-11-7,446-66-2
1-(4-chlorophenyl)-2,2,2-trifluoroethanol

: 1202576-98-4
Ethyl 3-{4-[1-(4-chlorophenyl)-2,2,2-trifluoroethoxy]phenyl}-3-ethoxypropionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / diethyl ether / 0 °C

1.2: 2 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

4.1: silver(l) oxide / toluene / 20 °C

With sodium hydride; caesium carbonate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;