1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine

Base Information

• Chemical Name: 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine
• CAS No.: 162510-55-6
• Molecular Formula: C₁₅H₂₁Cl₂N₃O
• Molecular Weight: 330.257
• Mol file: 162510-55-6.mol

Synonyms:1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine

Chemical Property of 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine

There total 9 articles about 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-(2'-chlorobenzyl)-4-methyl-2-<(hydroxyethylamino)carbonyl>piperazine (162510-54-5) → 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine (162510-55-6)

Guidance literature:

With thionyl chloride; In chloroform; for 12h;

DOI:10.1021/jm981099b

Reference yield: 50.0%

→ 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine (162510-55-6)

Guidance literature:

Reference yield:

ethyl 2-piperazinecarboxylate (89941-07-1) → 1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine (162510-55-6)

Guidance literature:

Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / -10 °C

2: K₂CO₃, KI / acetonitrile / 15 h / 80 °C

3: aq. HCl / acetone / 3 h / Ambient temperature

4: HCO₂H / methanol / 20 h / Heating

5: 1.) Al(CH₃)2 / 1.) toluene, 1 h, 2.) toluene, a) reflux, 4 h, b) RT, overnight

6: 62 percent / HCl, MeOH / 2 h

7: 61 percent / SOCl₂ / CHCl₃ / 12 h

With hydrogenchloride; methanol; formic acid; thionyl chloride; Al(CH₃)2; potassium carbonate; triethylamine; potassium iodide; In methanol; dichloromethane; chloroform; acetone; acetonitrile;

DOI:10.1021/jm981099b

upstream raw materials:

1-(2'-chlorobenzyl)-4-methyl-2-<(hydroxyethylamino)carbonyl>piperazine

ethyl 2-piperazinecarboxylate

1-chloro-2-(chloromethyl)benzene

1-(2-chlorobenzyl)-2-ethoxycarbonylpiperazine