tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane
CAS No.:170238-53-6
Molecular Formula:C₅₂H₆₆O₄Si
Molecular Weight:783.179
Hs Code.:

Synonyms:tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

There total 7 articles about tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 116-11-0
2-Methoxypropene

: (2R,3R,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-3-(2-trityloxy-ethyl)-dodecane-2,4-diol

: 170238-53-6
tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate; In acetone;
DOI:10.1021/ja00142a047

Reference yield:

: 76-83-5
trityl chloride

: 170238-53-6
tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DMAP, Et₃N / Ambient temperature

2: 1.) t-BuOK, 2.) H₂O₂, TBAF, KHCO₃ / 1.) DMSO

3: 76 percent / imidazole

4: 93 percent / PPTS / acetone

With 1H-imidazole; dmap; potassium tert-butylate; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium hydrogencarbonate; triethylamine; In acetone;
DOI:10.1021/ja00142a047

Reference yield:

: C₃₀H₅₄OSi₂

: 170238-53-6
tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 1,1,3,3-tetramethylbutyl isocyanide, Pd(OAc)2 / toluene / Ambient temperature

2: 1.) RhCl(PPh₃)2, catecholborane, 2.) H₂O₂, NaOAc

3: 86 percent / DMAP, Et₃N / Ambient temperature

4: 1.) t-BuOK, 2.) H₂O₂, TBAF, KHCO₃ / 1.) DMSO

5: 76 percent / imidazole

6: 93 percent / PPTS / acetone

With 1H-imidazole; dmap; palladium diacetate; [RhCl(Ph₃P)2]; 1,1,3,3-tetramethylbutane isonitrile; potassium tert-butylate; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium acetate; pyridinium p-toluenesulfonate; potassium hydrogencarbonate; triethylamine; benzo[1,3,2]dioxaborole; In acetone; toluene;
DOI:10.1021/ja00142a047