Technology Process of tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane
There total 7 articles about tert-Butyl-[(4R,5R,6R)-2,2-dimethyl-6-octyl-5-(2-trityloxy-ethyl)-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / DMAP, Et3N / Ambient temperature
2: 1.) t-BuOK, 2.) H2O2, TBAF, KHCO3 / 1.) DMSO
3: 76 percent / imidazole
4: 93 percent / PPTS / acetone
With
1H-imidazole; dmap; potassium tert-butylate; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium hydrogencarbonate; triethylamine;
In
acetone;
DOI:10.1021/ja00142a047
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1,1,3,3-tetramethylbutyl isocyanide, Pd(OAc)2 / toluene / Ambient temperature
2: 1.) RhCl(PPh3)2, catecholborane, 2.) H2O2, NaOAc
3: 86 percent / DMAP, Et3N / Ambient temperature
4: 1.) t-BuOK, 2.) H2O2, TBAF, KHCO3 / 1.) DMSO
5: 76 percent / imidazole
6: 93 percent / PPTS / acetone
With
1H-imidazole; dmap; palladium diacetate; [RhCl(Ph3P)2]; 1,1,3,3-tetramethylbutane isonitrile; potassium tert-butylate; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium acetate; pyridinium p-toluenesulfonate; potassium hydrogencarbonate; triethylamine; benzo[1,3,2]dioxaborole;
In
acetone; toluene;
DOI:10.1021/ja00142a047
