(4-Amino-phenyl)-hydroxy-acetic acid methyl ester

Base Information

Chemical Name:(4-Amino-phenyl)-hydroxy-acetic acid methyl ester
CAS No.:182918-73-6
Molecular Formula:C₉H₁₁NO₃
Molecular Weight:181.191
Hs Code.:
European Community (EC) Number:862-954-1

Synonyms:methyl 2-(4-aminophenyl)-2-hydroxyacetate;182918-73-6;(4-amino-phenyl)-hydroxy-acetic acid methyl ester;SCHEMBL2900372;GAMGLCCWIJAQFS-UHFFFAOYSA-N;Methyl2-(4-aminophenyl)-2-hydroxyacetate;CS-0371106;G73095;EN300-1723049

Suppliers and Price of (4-Amino-phenyl)-hydroxy-acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (4-Amino-phenyl)-hydroxy-acetic acid methyl ester

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:181.07389321
Heavy Atom Count:13
Complexity:176

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C(C1=CC=C(C=C1)N)O

Technology Process of (4-Amino-phenyl)-hydroxy-acetic acid methyl ester

There total 9 articles about (4-Amino-phenyl)-hydroxy-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 13305-09-4
methyl (±)-2-hydroxy-2-(4-nitrophenyl)acetate

: 182918-73-6
methyl (±)-2-(4-aminophenyl)-2-hydroxyacetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 18h;

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 182918-73-6
methyl (±)-2-(4-aminophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / SOCl₂ / 24 h / 20 °C

2: 85 percent / NBS / CCl₄ / 5 h / Irradiation

3: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

4: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

5: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

With N-Bromosuccinimide; tetrafluoroboric acid; thionyl chloride; hydrogen; palladium on activated charcoal; In methanol; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a

Reference yield:

: 2945-08-6
methyl (4-nitrophenyl)acetate

: 182918-73-6
methyl (±)-2-(4-aminophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NBS / CCl₄ / 5 h / Irradiation

2: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

3: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

4: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

With N-Bromosuccinimide; tetrafluoroboric acid; hydrogen; palladium on activated charcoal; In methanol; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a