tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate
CAS No.:1318754-73-2
Molecular Formula:C₂₂H₂₆F₃N₃O₃S
Molecular Weight:469.528
Hs Code.:

Synonyms:tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1318757-52-6
tert-butyl {4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamate

: 72925-16-7,72983-31-4,140148-70-5,59378-75-5
1-boc-pyrrolidine-3-carboxylic acid

: 1318754-73-2
tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl {4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamate; With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.166667h;

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; pH=9 - 10;

1-boc-pyrrolidine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1318754-73-2
tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2.1: pyridine / 7 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 0.5 h / 0 - 20 °C

3.2: ion exchange resin CG₅₀ / 0.5 h / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / 2 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 0.17 h / 20 °C

5.2: pH 9 - 10

5.3: 0 - 20 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; water; ethyl acetate;

Reference yield:

: 952182-78-4
2-(3-(trifluoromethyl)phenyl)ethanethioamide

: 1318754-73-2
tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 7 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 0.5 h / 0 - 20 °C

2.2: ion exchange resin CG₅₀ / 0.5 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / 2 h / 90 °C

4.1: hydrogenchloride / ethanol; water / 0.17 h / 20 °C

4.2: pH 9 - 10

4.3: 0 - 20 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In ethanol; water;