N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride

Base Information

Chemical Name:N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride
CAS No.:1318754-74-3
Molecular Formula:C₁₇H₁₈F₃N₃OS*ClH
Molecular Weight:405.872
Hs Code.:

Synonyms:N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride

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Technology Process of N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride

There total 1 articles about N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1318754-73-2
tert-butyl 3-({4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamoyl)pyrrolidine-1-carboxylate

: 1318754-74-3
N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 72.0%

: 1318754-74-3
N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride

: 75-36-5
acetyl chloride

: 1318754-75-4
1-acetyl-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide

Guidance literature:: N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}pyrrolidine-3-carboxamide hydrochloride; With hydrogenchloride; In water; ethyl acetate; for 0.0833333h;

acetyl chloride; In N,N-dimethyl acetamide; at 0 ℃; for 0.5h;