Triethylamine hydrofluoride

Base Information

• Chemical Name: Triethylamine hydrofluoride
• CAS No.: 73602-61-6
• Molecular Formula: C6H15N^.3HF
• Molecular Weight: 161.211
• Hs Code.: 29211910
• European Community (EC) Number: 249-702-0
• Mol file: 73602-61-6.mol

Synonyms:triethylamine hydrofluoride;Ethanamine, N,N-diethyl-, hydrofluoride (1:1);29585-72-6;Et3N.HF;SCHEMBL99441;Hydrogen fluoride triethylamine;NTJBWZHVSJNKAD-UHFFFAOYSA-N

Chemical Property of Triethylamine hydrofluoride

Chemical Property:

• Appearance/Colour: clear yellow liquid
• Vapor Pressure: 0.0235mmHg at 25°C
• Melting Point: -29 - -27 °C
• Refractive Index: n20/D 1.3915(lit.)
• Boiling Point: 70°C15mm Hg(lit.)
• Flash Point: 90.5 °C at 760 mmHg
• PSA: 3.24000
• Density: 0.989g/mLat 25°C(lit.)
• LogP: 2.94620
• Storage Temp.: Keep Cold
• Sensitive.: Hygroscopic
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 121.126677677
• Heavy Atom Count: 8
• Complexity: 25.7

Purity/Quality:

99% ^*data from raw suppliers

Triethylamine trihydrofluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+,C,Xi
• Hazard Codes: T+,T,C,Xi,F
• Statements: 26/27/28-35-36/37/38-20/21/22-11
• Safety Statements: 26-36/37/39-45-7/9-36/37-36-61-29-16-3

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC.F
• Uses: Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams. Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.

Technology Process of Triethylamine hydrofluoride

There total 5 articles about Triethylamine hydrofluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,2,3,3-tetrafluoropropanol (76-37-9) + perfluoropropanoyl fluoride (422-61-7) → triethylamine tris(hydrogen fluoride) (73602-61-6,23588-89-8,29585-72-6,94527-74-9) + 1H,1H,3H-perfluoropropyl perfluoropropionate

Guidance literature:

With triethylamine; at 5 - 20 ℃; for 5h;

Reference yield:

perfluoro(2-propoxypropionyl) fluoride (2062-98-8,125037-08-3,75566-60-8) + 2,2,3,3-tetrafluoropropanol (76-37-9) → triethylamine tris(hydrogen fluoride) (73602-61-6,23588-89-8,29585-72-6,94527-74-9) + 1H,1H,3H-perfluoropropyl perfluoro-α-propoxypropionate

Guidance literature:

With triethylamine; at 5 - 20 ℃;

Reference yield:

2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoyl fluoride (375-84-8) → triethylamine tris(hydrogen fluoride) (73602-61-6,23588-89-8,29585-72-6,94527-74-9) + 1H,1H,3H-perfluoropropyl perfluoroenanthate

Guidance literature:

With triethylamine; at 5 - 20 ℃;

upstream raw materials:

perfluoro(2-propoxypropionyl) fluoride

2,2,3,3-tetrafluoropropanol

perfluoropropanoyl fluoride

2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoyl fluoride

Downstream raw materials:

triethylammonium dihydrofluoride

biphenyl-2-ylcarbamic Acid 1-(2-{5-[(R)-2-(8-Benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]pentylcarbamoyl}ethyl)piperidin-4-yl Ester

N-[2-[4-[(3-phenyl-4-methoxyphenyl)amino]phenyl]ethyl]-(R)-2-hydroxy-2-(8-benzyloxy-1,2-dihydro-2-oxoquinolin-5-yl)ethylamine

5-Methyluridine

Refernces

Sintered silicon carbide: A new ceramic vessel material for microwave chemistry in single-mode reactors

10.1002/chem.201001703

The research explores the use of sintered silicon carbide (SiC) as a novel ceramic material for reaction vessels in microwave chemistry. The purpose of this study is to leverage SiC's high microwave absorptivity, thermal conductivity, and chemical inertness, which allows for efficient heating and improved control over reaction conditions, particularly in extreme temperature and pressure regimes. The conclusions drawn from the research indicate that SiC vessels provide almost complete shielding from electromagnetic fields, effectively separating thermal from specific/nonthermal microwave effects on chemical reactions. This technology enables the safe use of corrosive reagents at high temperatures and pressures, which is not feasible with standard glass vessels. The chemicals used in the process include a variety of solvents with different microwave absorbtivities, such as hexane, acetonitrile (MeCN), ethanol (EtOH), and 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF6), as well as reagents like triethylamine trihydrofluoride (TREAT-HF) and strong aqueous bases like potassium hydroxide (KOH) for various reaction scenarios.