2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

Base Information

Chemical Name:2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine
CAS No.:1377550-22-5
Molecular Formula:C₂₈H₂₈N₄O₄S
Molecular Weight:516.621
Hs Code.:

Synonyms:2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

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Chemical Property of 2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

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Technology Process of 2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

There total 4 articles about 2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1377551-31-9
C₁₄H₁₄BrClN₄O₂S

: 5720-07-0
4-methoxyphenylboronic acid

: 1377550-22-5
2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 2h;
DOI:10.1021/jm300403a

Reference yield:

: 313654-83-0
2-Chloro-3-(4-tert-butoxycarbonyl-1-piperazinyl)pyrazine

: 1377550-22-5
2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 2 h / 90 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; 3: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a

Reference yield:

: 2905-24-0
3-Bromobenzenesulfonyl chloride

: 1377550-22-5
2-(4-(4'-methoxybiphenyl-3-ylsulfonyl)piperazin-1-yl)-3-(4-methoxyphenyl)pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 2 h / 90 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a