3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide

Base Information

• Chemical Name: 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide
• CAS No.: 1309588-16-6
• Molecular Formula: C₂₅H₃₀ClN₅O₂S
• Molecular Weight: 500.064
• Mol file: 1309588-16-6.mol

Synonyms:3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide

Chemical Property of 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide

There total 5 articles about 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetohydrazide (1309588-10-0) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide (1309588-16-6)

Guidance literature:

With triethylamine; In benzene; for 10h; Reflux;

DOI:10.1007/s00044-010-9389-z

Reference yield:

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetic acid (1309588-07-5) → 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide (1309588-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 4 h / Reflux

1.2: 6 h / Reflux

2.1: triethylamine / benzene / 10 h / Reflux

With thionyl chloride; triethylamine; In benzene;

DOI:10.1007/s00044-010-9389-z

Reference yield:

2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide (306963-81-5) → 3-chloro-N'-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)propanehydrazide (1309588-16-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; potassium hydroxide / water / Reflux

2.1: ethanol / 4 h / Reflux

3.1: thionyl chloride / 4 h / Reflux

3.2: 6 h / Reflux

4.1: triethylamine / benzene / 10 h / Reflux

With hydrogenchloride; thionyl chloride; triethylamine; potassium hydroxide; In ethanol; water; benzene;

DOI:10.1007/s00044-010-9389-z

upstream raw materials:

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetic acid

2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetohydrazide

2-chloropropionyl chloride

ibuprofen

Downstream raw materials:

3-(2-(2-(2-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)acetyl)hydrazynyl)-3-oxopropyl nitrate