306963-81-5

Basic information

• Product Name: 2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide
• Synonyms: 2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide
• CAS NO: 306963-81-5
• Molecular Weight: 279.406
• Mol File: 306963-81-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide(306963-81-5)
• EPA Substance Registry System: 2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide(306963-81-5)

Safety Data

• Hazardous Substances Data: 306963-81-5(Hazardous Substances Data)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 127222-69-9 ibuprofen hydrazide 
• 333-20-0 potassium thioacyanate 
• 41283-72-1 ibuprofen ethyl ester 
• 15687-27-1 ibuprofen 
• 104400-52-4 2-(4-isobutylphenyl)propionic acid N-oxysuccinimide ester 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1282538-88-8 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(4-chlorophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-89-9 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(4-nitrophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-90-2 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(2-nitrophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-91-3 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(4-bromophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-93-5 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(3-chloro-4-fluorophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-94-6 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(2-methyl-6-nitrophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-95-7 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(2-methyl-4-nitrophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-96-8 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(4-chloro-2-nitrophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-97-9 2-[1-(4-isobutylphenyl)ethyl]-5-[(5-(3,4-dichlorophenyl)furan-2-yl)methylidene]-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-98-0 2-[1-(4-isobutylphenyl)ethyl]-5-(3,4-dimethoxybenzyl)-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282538-99-1 2-[1-(4-isobutylphenyl)ethyl]-5-(3,4-dimethoxy-2-nitrobenzyl)-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282539-00-7 2-[1-(4-isobutylphenyl)ethyl]-5-(4-hydroxybenzyl)-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 1282539-01-8 2-[1-(4-isobutylphenyl)ethyl]-5-(3,5-difluorobenzyl)-[1,3]thiazolo[3,2-b]-1,2,4-triazol-6(5H)-one 
• 471254-62-3 2-amino-5-(1-(4-isobutylphenyl)ethyl)-1,3,4-thiadiazole 

Relevant articles and documents

Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of new 2-(4-isobutylphenyl)propanoic acid derivatives

Synthesis and pharmacological evaluation of various 2-(4-isobutylphenyl) propanoic acid derivatives containing 1,3,4-thiadiazole and thiadiazolo[3,2-a] [1,3,5]triazine-5-thione nucleus is reported here. The structures of new compounds are supported by IR, 1H & 13C NMR data. These compounds were tested in vivo for their anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen were screened for their analgesic, ulcerogenic and lipid peroxidation activities. The compounds, which showed less ulcerogenic action, also showed reduced malondialdehyde production (MDA). Compound 4i and 5f showed 89.50 and 88.88% of inhibition in paw edema, 69.80 and 66.25% protection against acetic acid-induced writhings and 0.7 and 0.65 of severity index, respectively, compared to 90.12, 72.50 and 1.95 values of ibuprofen.

Synthesis, characterization and biological studies of some bioactive thiazolotriazole derivatives

The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in good yield from Ibuprofen (1). One-pot three-component reactions of 3 with 5-aryl-furan-2-carboxaldehydes/substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2, 4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities.