((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester
CAS No.:194934-97-9
Molecular Formula:C₂₈H₃₂FNO₄
Molecular Weight:465.565
Hs Code.:

Synonyms:((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Suppliers and Price of ((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

There total 4 articles about ((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 194934-96-8,129332-29-2
(E)-(3R,5S)-(+)-7-[3-(4-fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid 1,1-dimethylethyl ester

: 194934-97-9
((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(97)00686-8

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 194934-97-9
((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) NaBH₄, Et₂BOMe, 2.) aq. NaHCO₃, H₂O₂ / 1.) THF, MeOH, -78 deg C, 1.5 h, 2.) THF, MeOH, ethyl acetate, room temperature, 15 h

3: 70 percent / DDQ / tetrahydrofuran / Ambient temperature

With sodium tetrahydroborate; diethyl methoxy borane; dihydrogen peroxide; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran;
DOI:10.1016/S0040-4020(97)00686-8

Reference yield:

: 93957-50-7
3-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2(E)-propenal

: 194934-97-9
((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) NaBH₄, Et₂BOMe, 2.) aq. NaHCO₃, H₂O₂ / 1.) THF, MeOH, -78 deg C, 1.5 h, 2.) THF, MeOH, ethyl acetate, room temperature, 15 h

3: 70 percent / DDQ / tetrahydrofuran / Ambient temperature

With sodium tetrahydroborate; diethyl methoxy borane; dihydrogen peroxide; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran;
DOI:10.1016/S0040-4020(97)00686-8