3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

Base Information

Chemical Name:3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride
CAS No.:133390-70-2
Molecular Formula:C₁₈H₁₇N₃O₃*ClH
Molecular Weight:359.812
Hs Code.:

Synonyms:3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

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Chemical Property of 3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

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Technology Process of 3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

There total 3 articles about 3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 133390-68-8
4,6-Dioxo-6-(3-pyridyl)hexanoic Acid

: 133390-70-2
3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

Guidance literature:: With triethylamine; In methanol; for 6h; Ambient temperature;
DOI:10.1055/s-1991-26367

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 133390-68-8
4,6-Dioxo-6-(3-pyridyl)hexanoic Acid

: 121-44-8
triethylamine

: 133390-70-2
3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

Guidance literature:: In methanol;

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 133390-70-2
3-[1-(4-methoxyphenyl)-5-(pyridin-3-yl)-3-pyrazolyl]-propionic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) heptane, THF, sonicate, 0 deg C, 10 min, 2.) sonicate, 0 deg C, 30 min

2: 76 percent / NEt₃ / methanol / 6 h / Ambient temperature

With triethylamine; lithium hexamethyldisilazane; In methanol;
DOI:10.1055/s-1991-26367