4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

Base Information

Chemical Name:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime
CAS No.:1586758-82-8
Molecular Formula:C₂₃H₂₄F₂N₂O₂
Molecular Weight:398.453
Hs Code.:

Synonyms:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

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Chemical Property of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

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Technology Process of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

There total 9 articles about 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

: 2550-36-9
Cyclohexylmethyl bromide

: 1586758-82-8
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

Guidance literature:: N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Cyclohexylmethyl bromide; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jf500461a DOI:10.1021/jf500461a

Reference yield: 43.8%

: 1586758-82-8
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 1h;

In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1586758-82-8
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-cyclohexylmethyl oxime

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

2.2: 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 2.83 h / Reflux

5.1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

6.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

7.2: 2 h

With chromium(VI) oxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; iodine; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a