N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

Base Information

Chemical Name:N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide
CAS No.:1586758-78-2
Molecular Formula:C₁₆H₁₃ClF₂N₂O₂
Molecular Weight:338.741
Hs Code.:

Synonyms:N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

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Chemical Property of N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

Chemical Property:

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Technology Process of N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

There total 7 articles about N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1586758-77-1
N-(2-chloro-1-(4-formylphenyl)ethyl)-2,6-difluorobenzamide

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; for 4h; Molecular sieve; Reflux;
DOI:10.1021/jf500461a DOI:10.1021/jf500461a

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

2.2: 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 2.83 h / Reflux

5.1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

6.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

With chromium(VI) oxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; iodine; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jf500461a

Reference yield:

: 1586758-76-0
N-(2-chloro-1-(p-tolyl)ethyl)-2,6-difluorobenzamide

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

2: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

With chromium(VI) oxide; sulfuric acid; hydroxylamine hydrochloride; acetic acid; triethylamine; In tetrahydrofuran;
DOI:10.1021/jf500461a