103577-61-3

Basic information

• Product Name: 2, 3-Dimethyl-4-(2,2,2-Trifluoroethpxy) Pyridine-N-Oxide
• Synonyms: 2, 3-Dimethyl-4-(2,2,2-Trifluoroethpxy) Pyridine-N-Oxide;2,3-Dimethyl-4-Trifluoroethoxypyridine-N-Oxide;2,3-Dimethyl-4-(2,2,2-trifluoroethoxy)pyridine 1-oxide;2,3-dimethyl-1-oxido-4-(2,2,2-trifluoroethoxy)pyridin-1-ium;Lansoprazole Impurity 2
• CAS NO: 103577-61-3
• Molecular Formula: C₉H₁₀F₃NO₂
• Molecular Weight: 221.1764096
• Mol File: 103577-61-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 131-132 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 321.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: 2, 3-Dimethyl-4-(2,2,2-Trifluoroethpxy) Pyridine-N-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2, 3-Dimethyl-4-(2,2,2-Trifluoroethpxy) Pyridine-N-Oxide(103577-61-3)
• EPA Substance Registry System: 2, 3-Dimethyl-4-(2,2,2-Trifluoroethpxy) Pyridine-N-Oxide(103577-61-3)

Safety Data

• Hazardous Substances Data: 103577-61-3(Hazardous Substances Data)

Usage

Uses

2,3-Dimethyl-4-(2,2,2-trifluoroethoxy)pyridine 1-Oxide is a useful intermediate in the synthesis of the proton pump inhibitor lansoprazole.

Upstream product

• 37699-43-7 2,3-dimethyl-4-nitropyridine N-oxide 
• 75-89-8 2,2,2-trifluoroethanol 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 22710-07-2 2,3-dimethylpyridine 1-oxide 
• 583-61-9 2,3-Lutidine 
• 59886-90-7 4-chloro-2,3-dimethylpyridine-N-oxide 

Downstream Products

• 253345-80-1 C₉H₁₀F₃NO₂*ClH 
• 103577-45-3 lansoprasole 
• 103577-40-8 lansoprazole sulfide 
• 128430-66-0 2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine 
• 103577-66-8 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine 
• 112525-75-4 2-acetoxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine 

Relevant articles and documents

Safety evaluation of an unexpected incident with a nitro compound

An unexpected highly exothermic reaction followed by explosion has been studied by means of reaction calorimetry and adiabatic calorimetry. The investigation of the process shows that the incident took place by a local adiabatic temperature rise in the reactor vessel due to the presence of potassium carbonate, which activated the decomposition of a nitro compound with an unusual low temperature onset The study is completed with an unproved and safer procedure consisting of changing the order of chemicals addition as an alternative approach.

Diversified synthesis of novel quinoline and dibenzo thiazepine derivatives using known active intermediates

The novel drug development to control resisting infections in conventional drug therapy is a need of today. Few antiulcer relative derivatives developed by approaching convergent synthesis. The derivatives synthesized successfully are dibenzo thiazepine-pyridine (SLN11-SLN15) and benzimidazole-hydroquinoline based derivatives (SLN16-SLN20). It involved the coupling through microwave, sonication and conventional techniques at final step. The efficient technology identified as sonication technique basically time and yield. The reported compounds were structural characterized by elemental analysis and spectral studies such as 1H, 13C NMR and MS.

Crystals of benzimidazole derivatives and their production

A substantially solvent-free and stable crystal of the compound of the formula: STR1 wherein the ring A may optionally be substituted, R1 represents hydrogen or an N-protecting group, each of R2, R3 and R4 (1) a hydrogen atom, (2) an alkyl group which may optionally be substituted with halogen atom(s) or (3) an alkoxy group which may optionally be substituted with halogen atom(s) or alkoxy; or its salt, is produced by subjecting a solvate of the compound (I) or its salt to de-solvent treatment, in an industrially advantageous method.