FMOC-D-3,3-DIPHENYLALANINE

Base Information

• Chemical Name: FMOC-D-3,3-DIPHENYLALANINE
• CAS No.: 189937-46-0
• Molecular Formula: C₃₀H₂₅NO₄
• Molecular Weight: 463.533
• Hs Code.: 2922498590
• Mol file: 189937-46-0.mol

Synonyms:(R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3,3-diphenylpropanoic acid

Chemical Property of FMOC-D-3,3-DIPHENYLALANINE

Chemical Property:

• Vapor Pressure: 3.18E-19mmHg at 25°C
• Melting Point: 116.5-119.5℃(lit.)
• Boiling Point: 676.5oC at 760 mmHg
• PKA: 3.57±0.10(Predicted)
• Flash Point: 362.9oC
• PSA: 75.63000
• Density: 1.262g/cm3
• LogP: 6.20130
• Storage Temp.: Store at 0°C

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-3- ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-d-3,3-diphenylalanine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Technology Process of FMOC-D-3,3-DIPHENYLALANINE

There total 1 articles about FMOC-D-3,3-DIPHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 2-amino-3,3-diphenylpropionic acid (62653-26-3) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,3-diphenyl-propionic acid (839719-72-1,189937-46-0,201484-50-6)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm049906w

Reference yield: 100.0%

Fmoc-Leu-preloaded Wang resin, deprotected + N-(9-fluorenylmethoxycarbonyl)-D-leucine (35661-60-0,126727-03-5,114360-54-2) + Fmoc-N-methylvaline (103478-58-6,84000-11-3) + Fmoc-3,3-diphenyl-D-alanine (189937-46-0,201484-50-6) + FMOC-(4-methoxy-D-phenylalanine) (201335-88-8) → HO-Leu-N-Me-Val-D-Leu-D-Tyr(Me)-3,3-diphenyl-D-Ala-NH2 (1610523-76-6)

Guidance literature:

Fmoc-Leu-preloaded Wang resin, deprotected; Fmoc-N-methylvaline; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; 2-chlorotrityl-leucine resin

With piperidine; In N,N-dimethyl-formamide; isopropyl alcohol; for 0.433333h; 2-chlorotrityl-leucine resin

N-(9-fluorenylmethoxycarbonyl)-D-leucine; Fmoc-3,3-diphenyl-D-alanine; FMOC-(4-methoxy-D-phenylalanine); Further stages;

DOI:10.1021/ml500114p

Reference yield: 96.0%

Fmoc-Leu-preloaded Wang resin, deprotected + Fmoc-D-3-(4-pyridyl)Ala-OH (205528-30-9) + N-(9-fluorenylmethoxycarbonyl)-D-leucine (35661-60-0,126727-03-5,114360-54-2) + Fmoc-N-methylvaline (103478-58-6,84000-11-3) + Fmoc-3,3-diphenyl-D-alanine (189937-46-0,201484-50-6) → HO-Leu-N-Me-Val-D-Leu-D-3-(4-pyridyl)Ala-3,3-diphenyl-D-Ala-NH2 (1610523-74-4)

Guidance literature:

Fmoc-Leu-preloaded Wang resin, deprotected; Fmoc-N-methylvaline; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; 2-chlorotrityl-leucine resin

With piperidine; In N,N-dimethyl-formamide; isopropyl alcohol; for 0.433333h; 2-chlorotrityl-leucine resin

Fmoc-D-3-(4-pyridyl)Ala-OH; N-(9-fluorenylmethoxycarbonyl)-D-leucine; Fmoc-3,3-diphenyl-D-alanine; Further stages;

DOI:10.1021/ml500114p

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

2-amino-3,3-diphenylpropionic acid

Refernces