3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester

Base Information

Chemical Name:3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester
CAS No.:57192-17-3
Molecular Formula:C₁₇H₁₉ClO₇
Molecular Weight:370.787
Hs Code.:

Synonyms:3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester

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Chemical Property of 3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester

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Technology Process of 3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester

There total 3 articles about 3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 29582-39-6,6269-33-6
3-(4-chlorobenzoyl)acrylic acid

: 105-53-3
diethyl malonate

: 57192-17-3
3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester

Guidance literature:: With sodium hydroxide; In ethanol; at 40 ℃; for 24h;
DOI:10.1002/jccs.200500173

Reference yield:

: 108-90-7
chlorobenzene

: 57192-17-3
3-carboxy-5-(4-chlorophenyl)-2-ethoxycarbonyl-5-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / AlCl₃ / 20 °C

2: 65 percent / NaOH / ethanol / 24 h / 40 °C

With sodium hydroxide; aluminium trichloride; In ethanol; 2: Michael reaction;
DOI:10.1002/jccs.200500173