6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

Base Information

Chemical Name:6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester
CAS No.:890128-75-3
Molecular Formula:C₂₅H₁₈F₃N₃O₄
Molecular Weight:481.431
Hs Code.:

Synonyms:6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

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Chemical Property of 6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

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Technology Process of 6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

There total 2 articles about 6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2437-17-4
6-hydroxy-1-naphthoic acid

: 890128-75-3
6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / acetone / 3 h / 20 °C / Inert atmosphere

2: triethylamine; dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 30 h / 110 °C / 90009 Torr / Autoclave; Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.5b01582

Reference yield:

: 890129-79-0
6-(6-chloro pyrimidin-4-yloxy)naphthalene-1-carboxylic acid

: 890128-75-3
6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 30 h / 110 °C / 90009 Torr / Autoclave; Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01582

Reference yield: 61.0%

: 890128-75-3
6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

: 890128-81-1
6-(6-hydroxymethyl pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide

Guidance literature:: With sodium tetrahydroborate; In tert-butyl alcohol; at 65 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01582