12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Base Information

Chemical Name:12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one
CAS No.:882697-83-8
Molecular Formula:C₃₀H₂₈N₂O₂
Molecular Weight:448.565
Hs Code.:

12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1<i>H</i>-indolo[2,3-<i>a</i>]quinolizin-4-one

Synonyms:12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

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Chemical Property of 12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

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Technology Process of 12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

There total 3 articles about 12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 882697-82-7
12-benzyl-6-benzyloxymethyl-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one

: 882697-83-8
12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Guidance literature:: 12-benzyl-6-benzyloxymethyl-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one; With Phenylselenyl bromide; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 24h;

With sodium periodate; sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 18h;
DOI:10.1016/j.tetlet.2006.01.081

Reference yield:

: 100-39-0
benzyl bromide

: 882697-83-8
12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / NaH / dimethylformamide / 1 h / 20 °C

2.1: LDA; PhSeBr / tetrahydrofuran / 24 h / -78 - 20 °C

2.2: 85 percent / NaIO₄; NaHCO₃ / methanol; H₂O / 18 h / 20 °C

With Phenylselenyl bromide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.01.081

Reference yield:

: 778591-55-2
(6S,12bR)-1,2,3,6,7,12b-hexahydro-6-(hydroxymethyl)indolo[2,3-a]quinolizin-4(12H)-one

: 882697-83-8
12-benzyl-6-benzyloxymethyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / NaH / dimethylformamide / 1 h / 20 °C

2.1: LDA; PhSeBr / tetrahydrofuran / 24 h / -78 - 20 °C

2.2: 85 percent / NaIO₄; NaHCO₃ / methanol; H₂O / 18 h / 20 °C

With Phenylselenyl bromide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.01.081