4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

Base Information

Chemical Name:4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide
CAS No.:1382992-84-8
Molecular Formula:C₂₁H₁₈ClFN₆O
Molecular Weight:424.865
Hs Code.:

Synonyms:4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

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Chemical Property of 4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

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Technology Process of 4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

There total 8 articles about 4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-02-9
6-(1-Aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-carboxamide

: 767-69-1
6-bromopurine

: 1382992-84-8
4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; Inert atmosphere;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382992-84-8
4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / acetic acid / 18 h / 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 1 h / 200 °C

3.1: triethylamine / dichloromethane / -78 - 20 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2 h / 80 °C / Inert atmosphere

5.1: potassium hydroxide / ethanol / 2 h / Reflux

6.1: ammonium acetate / methanol; acetonitrile / 0.5 h / 65 °C / Sealed tube

6.2: 4 h / 65 °C

7.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 90 °C / Inert atmosphere

With N-Bromosuccinimide; ammonium acetate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; acetic acid; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1312686-23-9
6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate

: 1382992-84-8
4-Chloro-3'-fluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2 h / 80 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol / 2 h / Reflux

3.1: ammonium acetate / methanol; acetonitrile / 0.5 h / 65 °C / Sealed tube

3.2: 4 h / 65 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 90 °C / Inert atmosphere

With ammonium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; isopropyl alcohol; toluene; acetonitrile;