6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate
• CAS No.: 1312686-23-9
• Molecular Formula: C₁₁H₇ClF₃NO₄S
• Molecular Weight: 341.695
• Mol file: 1312686-23-9.mol

Synonyms:6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate

Chemical Property of 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate

There total 5 articles about 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.1%

trifluoromethylsulfonic anhydride (358-23-6) + 3-acetyl-5-chloro-2-hydroxy-6-methylbenzonitrile (1312686-22-8) → 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate (1312686-23-9)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 0.5h;

Reference yield: 42.0%

3-acetyl-5-chloro-2-hydroxy-6-methylbenzonitrile (1312686-22-8) + trifluoromethanesulfonic acid anhydride (1025373-45-8) → 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate (1312686-23-9)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 0.5h;

Reference yield:

1-(3-bromo-5-chloro-2-hydroxy-4-methylphenyl)ethanone → 6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate (1312686-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 1 h / 200 °C

2: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

With triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;

upstream raw materials:

trifluoromethylsulfonic anhydride

3-acetyl-5-chloro-2-hydroxy-6-methylbenzonitrile

5'-chloro-2'-hydroxy-4'-methyl acetophenone

1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethanone

Downstream raw materials:

1-[5-chloro-8-(3-fluorophenyl)isoquinolin-7-yl]ethanol

7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)isoquinoline

4-chloro-3'-fluoro-3-methyl-6-{1-[(9H-purin-6-yl)amino]ethyl}-[1,1'-biphenyl]-2-carbonitrile

N-{1-[4-chloro-3'-fluoro-5-methyl-6-(1H-tetrazol-5-yl)biphenyl-2-yl]ethyl}-9H-purin-6-amine