tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

Base Information

Chemical Name:tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate
CAS No.:1160502-52-2
Molecular Formula:C₂₂H₃₆BNO₄
Molecular Weight:389.343
Hs Code.:

Synonyms:tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

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Chemical Property of tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

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Technology Process of tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

There total 5 articles about tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₁₆H₂₄BrNO₂

: 73183-34-3
bis(pinacol)diborane

: 1160502-52-2
tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 90 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: 31938-07-5
(3-bromophenyl)acetonitrile

: 1160502-52-2
tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.83 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.67 h / 0 °C

2.2: 2 h / 0 °C

3.1: alane-N,N-dimethylethylamine complex / toluene; tetrahydrofuran / 0 - 20 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; alane-N,N-dimethylethylamine complex; potassium acetate; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; toluene; mineral oil;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: rac-2-(3-bromophenyl)propanenitrile

: 1160502-52-2
tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.67 h / 0 °C

1.2: 2 h / 0 °C

2.1: alane-N,N-dimethylethylamine complex / toluene; tetrahydrofuran / 0 - 20 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; alane-N,N-dimethylethylamine complex; potassium acetate; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; toluene; mineral oil;
DOI:10.1021/acsmedchemlett.9b00134