tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

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Chemical Name:tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate
CAS No.:1160502-32-8
Molecular Formula:C₄₂H₄₁F₃N₄O₂
Molecular Weight:690.808
Hs Code.:

Synonyms:tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

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Chemical Property of tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

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Technology Process of tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

There total 10 articles about tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1160502-52-2
tert-butyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butylcarbamate

: 1160502-31-7
4-iodo-3-(trifluoromethyl)-1-tritylpyrazolo[5,4-b]pyridine

: 1160502-32-8
tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

Guidance literature:: With sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; water; at 60 ℃;

Reference yield:

: 113975-22-7
2-fluoro-3-iodopyridine

: 1160502-32-8
tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 2 h / -70 °C

1.2: 1 h / -70 °C

2.1: manganese(IV) oxide / toluene / 0.5 h / Reflux

3.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 90 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

4.2: 2 h / 0 - 20 °C

5.1: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 60 °C / Inert atmosphere

With manganese(IV) oxide; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium hydride; sodium carbonate; hydrazine hydrate; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: 1160502-28-2
2,2,2-trifluoro-1-(2-fluoro-4-iodopyridin-3-yl)ethanol

: 1160502-32-8
tert-butyl 2-methyl-2-(3-(3-(trifluoromethyl)-1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-butylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / toluene / 0.5 h / Reflux

2.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 90 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 60 °C / Inert atmosphere

With manganese(IV) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium hydride; sodium carbonate; hydrazine hydrate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acsmedchemlett.9b00134