N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Base Information

• Chemical Name: N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine
• CAS No.: 93134-40-8
• Molecular Formula: C₄₃H₄₉N₃O₇Si
• Molecular Weight: 747.963

Synonyms:N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Chemical Property of N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Chemical Property:

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Technology Process of N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

There total 7 articles about N⁴-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → N4-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-40-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jo00199a032

Reference yield:

N4-benzoyl-2'-deoxycytidine (4836-13-9) → N4-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / Ambient temperature

2: imidazole / dimethylformamide / 15 h / Ambient temperature

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/jm990050i

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N4-Benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / Ambient temperature

2: imidazole / dimethylformamide / 15 h / Ambient temperature

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/jm990050i

upstream raw materials:

tert-butyldimethylsilyl chloride

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

4,4'-dimethoxytrityl chloride

benzoic acid anhydride

Downstream raw materials:

N⁶-Benzoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxyadenosyl-(3'5')-N⁴-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

C₅₄H₆₄N₅O₁₄PSi

C₄₈H₅₀N₅O₁₄P

(E)-3-[(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-acrylic acid ethyl ester

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