N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Base Information

Chemical Name:N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide
CAS No.:1445890-29-8
Molecular Formula:C₁₈H₁₅ClN₄O₂
Molecular Weight:354.796
Hs Code.:

Synonyms:N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

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Chemical Property of N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

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Technology Process of N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

There total 6 articles about N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 60-35-5
acetamide

: 1445890-27-6
1-[3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazol-4-yl]ethanone

: 1445890-29-8
N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 135 ℃; for 2h; Sealed tube; Microwave irradiation;

Reference yield:

: 700811-29-6
(2-chloropyridin-4-yl)hydrazine

: 1445890-29-8
N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 1 h / 20 °C

2: trichlorophosphate / 0.5 h / 20 °C

3: hydrogenchloride / tetrahydrofuran; diethyl ether / 1 h / 0 °C

4: pyridinium chlorochromate / dichloromethane / 20 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 135 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; pyridinium chlorochromate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; acetic acid;

Reference yield:

: 1445890-23-2
3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-4-carbaldehyde

: 1445890-29-8
N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran; diethyl ether / 1 h / 0 °C

2: pyridinium chlorochromate / dichloromethane / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 135 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; pyridinium chlorochromate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;